Sunday could be a long day for Andrew Luck and the Indianapolis Colts.

That’s because the Denver Broncos and their No. 1 defense is coming to town Sunday. Denver’s D is No. 1 in points allowed (112), yards (1,828), passing yards (1,203), passing touchdowns (5) and their 17 forced turnovers are second-best. And, no one puts pressure on the quarterback like the Broncos, with their NFL-best 29.0 sacks.

Andrew Luck under pressure

2015: 33/91, 4 TDs 6 INT, 36.8 Passer Rating

2014: 118/248, 13 TDs, 7 INTs, 75.7 Passer Rating

— PFF (@PFF) November 5, 2015

You know what they say: If you can’t stand the heat, get out of the kitchen.

Of course, with Von Miller, DeMarcus Ware, Malik Jackson, Antonio Smith, Shaquil Barrett and more relentless pass-rushers, there’s not much Luck or any other quarterback can do besides run for their quarterbacking life.

Last week, Denver’s phenomenal defense held Aaron Rodgers to a career-low 77 passing yards, sacked him three times and also forced a safety on the Green Bay Packers offense. What could happen this week?

Luck has thrown an NFL-high 12 interceptions in only six games played and has been sacked 14 times, which is middle of the pack. So, expect the Broncos to sack him at least twice Sunday, though, it could be an even more dominant day for the unit.