The Denver Broncos are headed to San Francisco for a huge Week 5 matchup with the 49ers!

Can Bo Nix and Sean Payton keep the Denver Broncos rolling after their Sunday Night Football win over the Los Angeles Rams? What will Denver’s defense need to do to slow down the 49ers? And which matchups could decide Broncos vs. 49ers on Sunday?

The DNVR Broncos Podcast breaks down everything you need to know before Denver takes on San Francisco, including the biggest keys to the game, players to watch, injury storylines and our Broncos vs. 49ers predictions.

Plus, what would a win in San Francisco mean for the Broncos as they continue their push through the 2026 NFL season?

On the DNVR Broncos Podcast, Zac Stevens, Ryan Koenigsberg and Henry Chisholm are coming to you LIVE from the DNVR Bar to break down all of the latest news in Broncos Country.

Intro: 0:00
Welcome in: 1:00
Broncos not respected yet: 10:32
The Broncos opportunity: 18:16
Game injury report: 24:08
Broncos keys to the game: 33:38
Shady rays the future is bright: 44:45
AFC West and Broncos predictions: 51:05

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An ALLCITY Network Production